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M2-MACROPHAGE conditioned medium

Intervention

2 papers study it5 findings

Across all fields, 2 papers: none in people yet, 2 in cells

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 2 independent labs in 2 countries
  • 1 finding against
  • Funders: China Postdoctoral Science Foundation and 3 more
  • Cells2

Outcomes

4

Cellular senescence

upin human cells1downin human cells1

2 studies

  1. M2-MACROPHAGE conditioned medium induces cellular senescence in human cells.

    “CM-M2, as well as a pro-senescence agent, hydrogen peroxide (H2O2), increased p21+-MSC number”

    Cellsin vitroadipose tissue

    M2-Macrophage-Induced Chronic Inflammation Promotes Reversible Mesenchymal Stromal Cell Senescence and Reduces Their Anti-Fibrotic Properties

    International journal of molecular sciences

  2. M2-MACROPHAGE conditioned medium decreases cellular senescence in human cells.

    “Moreover, TNF-α treatment enhanced apoptosis, senescence, and expression of inflammatory factor-related genes, including interleukin-6, MMP-13, ADAMTS-4, and ADAMTS-5, whereas M2CM coculture significantly reversed these effects.”

    Cellsin TNF-α-treated human NPCs

    M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

More on Cellular senescence

Intervertebral disc degeneration

downin mouse cells1

1 study

  1. M2-MACROPHAGE conditioned medium decreases intervertebral disc degeneration in mouse cells.

    “Using our established three-dimensional murine IVD organ culture model, we show that M2CM suppressed the inhibitory effect of TNF-α-rich environment.”

    Cellsin mouse IVD organ culture model treated with TNF-α

    M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

More on Intervertebral disc degeneration

Extracellular matrix synthesis

upin human cells1

1 study

  1. M2-MACROPHAGE conditioned medium increases extracellular matrix synthesis in human cells.

    “In addition, co-culture with M2CM promoted aggrecan and collagen II synthesis, but reduced collagen Iα1 levels in TNF-α treatment groups.”

    Cellsin TNF-α-treated human NPCs

    M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Apoptosis

downin human cells1

1 study

  1. M2-MACROPHAGE conditioned medium decreases apoptosis in human cells.

    “Moreover, TNF-α treatment enhanced apoptosis, senescence, and expression of inflammatory factor-related genes, including interleukin-6, MMP-13, ADAMTS-4, and ADAMTS-5, whereas M2CM coculture significantly reversed these effects.”

    Cellsin TNF-α-treated human NPCs

    M2 macrophage-conditioned medium inhibits intervertebral disc degeneration in a tumor necrosis factor-α-rich environment

    Journal of orthopaedic research : official publication of the Orthopaedic Research Society

More on Apoptosis

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