Lysergic acid diethylamide

1. Lysergic acid diethylamide decreases amyloid-β-induced structural and molecular alterations in cells.

   “LSD counteracts amyloid-β-induced structural and molecular alterations in primary cortical neurons”

   Cellsamyloid-β exposureprimary cortical neurons

   Lysergic acid diethylamide reverses aging- and neurodegeneration-associated brain transcriptional programs

   bioRxiv (Cold Spring Harbor Laboratory)·29 May 2026Preprint

1. Lysergic acid diethylamide decreases body size in worms.

   “LSD induces several phenotypes that overlap with those observed in some caloric restriction paradigms, including reduced reproductive output, decreased body size”

   Model organisms

   Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans

   bioRxiv (Cold Spring Harbor Laboratory)·17 Jun 2025Preprint

1. Lysergic acid diethylamide decreases reproductive output in worms.

   “LSD induces several phenotypes that overlap with those observed in some caloric restriction paradigms, including reduced reproductive output”

   Model organisms

   Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans

   bioRxiv (Cold Spring Harbor Laboratory)·17 Jun 2025Preprint

1. Lysergic acid diethylamide decreases lipofuscin in worms.

   “LSD treatment significantly extends lifespan in Caenorhabditis elegans and reduces age-associated lipofuscin accumulation”

   Model organisms

   Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans

   bioRxiv (Cold Spring Harbor Laboratory)·17 Jun 2025Preprint

More on Lipofuscin

1. Lysergic acid diethylamide extends lifespan in worms.

   “LSD treatment significantly extends lifespan in Caenorhabditis elegans”

   Model organisms

   Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans

   bioRxiv (Cold Spring Harbor Laboratory)·17 Jun 2025Preprint

1. Lysergic acid diethylamide is associated with aging- and neurodegeneration-associated transcriptional programs in silico.

   “we show that LSD induces gene expression patterns strongly anti-correlated with aging and neurodegeneration programs.”

   In silicoRodent LSD-induced profiles compared with human prefrontal cortex aging- and dementia-associated expression changesbrainchronic treatment

   Lysergic acid diethylamide reverses aging- and neurodegeneration-associated brain transcriptional programs

   bioRxiv (Cold Spring Harbor Laboratory)·29 May 2026Preprint

More on Aging- and neurodegeneration-associated transcriptional programs