Low socioeconomic status

5 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

4 independent labs in 3 countries

Funders: Universität Kassel and 1 more

Human trial1
Humans3

Outcomes

Cognitive function

downin humans2

2 studies

Low socioeconomic status impairs cognitive function in humans.
“those who had trajectories of downward mobility or those who faced persistent, prolonged exposure to low socioeconomic status across the life course had the lowest levels of cognition”
Humans
Socioeconomic Status Across the Life Course and Old Age Cognition
GSA 2025 abstract31 Dec 2025
Low socioeconomic status decreases cognitive function in humans (B=-0.20, 95% CI -0.34 to -0.06).
“low vs high: B=‐0.20, 95%CI=‐0.34 to ‐0.06”
Humansadjusted for demographics and LIBRAn = 1,048
Education, socioeconomic status, modifiable dementia risk and cognitive performance in older adults at risk of cognitive decline: a cross‐sectional study of the FINGER‐NL trial
AAIC 2025 abstract23 Dec 2025

LIBRA index

upin humans1

1 study

Low socioeconomic status increases LIBRA index in humans (B=0.53, 95% CI 0.15 to 0.92).
“low vs high: B=0.53, 95%CI=0.15 to 0.92”
Humansn = 1,048
Education, socioeconomic status, modifiable dementia risk and cognitive performance in older adults at risk of cognitive decline: a cross‐sectional study of the FINGER‐NL trial
AAIC 2025 abstract23 Dec 2025

Associations

Metabolically unhealthy obesity

upin humans1

1 study

Low socioeconomic status predicts metabolically unhealthy obesity in humans (aOR 2.48).
“Among younger adults, low SES predicted MUOB (aOR=2.48)”
Humans
Title: Variation in Cardiometabolic Phenotypes by Psychosocial and Socioeconomic Stress. The Role of Sex and Age in Hispanic/Latino Adults.
AHA Scientific Sessions 2025 abstract3 Nov 2025
Low socioeconomic status is associated with metabolically unhealthy obesity in humans (aOR 3.31, 95% CI 1.76–6.20).
“Among women, low SES was strongly associated with metabolically unhealthy obesity (MUOB; aOR=3.31, 95% CI: 1.76–6.20)”
Humansfemales
Title: Variation in Cardiometabolic Phenotypes by Psychosocial and Socioeconomic Stress. The Role of Sex and Age in Hispanic/Latino Adults.
AHA Scientific Sessions 2025 abstract3 Nov 2025