Low-protein, high-carbohydrate diet

2 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Health and Medical Research Council

Animals1

Outcomes

Lifespan

upin mice2

2 studies

Low-protein, high-carbohydrate diet extends lifespan in mice.
“a low-protein, high-carbohydrate (LPHC) diet enriched with non-digestible cellulose, extends lifespan in mice by shifting the liver proteome through altered RNA splicing”
Reviewenriched with non-digestible celluloseliver
Exploring Splicing-Energy Axis Associations to Diet and Longevity
Aging cell29 Dec 2025
Low-protein, high-carbohydrate diet extends lifespan in mice.
“Both approaches similarly enhanced longevity and metabolic health in mice relative to a control diet.”
Animals
An Ad Libitum-Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts via Opposite Effects on the Energy-Splicing Axis
Aging cell21 Oct 2025

Oxidative phosphorylation

downin mice1

1 study

Low-protein, high-carbohydrate diet decreases oxidative phosphorylation in mice.
“By contrast, the LPHC diet reduced these pathways but increased the abundance of proteins associated with RNA metabolism and spliceosome pathways.”
Animalsliver
An Ad Libitum-Fed Diet That Matches the Beneficial Lifespan Effects of Caloric Restriction but Acts via Opposite Effects on the Energy-Splicing Axis
Aging cell21 Oct 2025