AgingResearch.NewsJoin free

Low hydrogel stiffness

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: American Heart Association and 5 more
  • Cells1

Outcomes

2

Senescence-associated secretory phenotype (SASP)

upin cells1

1 study

  1. Low hydrogel stiffness increases senescence-associated secretory phenotype (SASP) in cells.

    “an attendant increase in expression of NF-κB-responsive inflammatory genes that typify the senescence-associated secretory phenotype (SASP).”

    Cellson low-stiffness hydrogels

    Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype

    American journal of physiology. Heart and circulatory physiologyOct 27, 2023

More on Senescence-associated secretory phenotype (SASP)

Cellular senescence

upin cells1

1 study

  1. Low hydrogel stiffness induces cellular senescence in cells.

    “lower substrate stiffness concomitantly augmented CF senescence, marked by elevated senescence-associated β-galactosidase (SA-β-Gal) activity and increased expression of p16 and p21”

    Cellson low vs high stiffness hydrogels

    Substrate stiffness modulates cardiac fibroblast activation, senescence, and proinflammatory secretory phenotype

    American journal of physiology. Heart and circulatory physiologyOct 27, 2023

More on Cellular senescence

Latest

Related