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Liver x receptor agonist

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Animals1

Outcomes

3

Inflammation

downin mice1

1 study

  1. Liver x receptor agonist decreases inflammation in mice.

    “Concomitantly, markers of neuroinflammation, CD14, MAC1, CD11c, and inducible nitric oxide synthase, were reduced”

    Animalsin NPC1 micebrain

    Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse

    The Journal of neuroscience : the official journal of the Society for Neuroscience26 Dec 2007

More on Inflammation

Lifespan

upin mice1

1 study

  1. Liver x receptor agonist extends lifespan in mice.

    “Treatment with this LXR agonist increased cholesterol excretion out of brain from 17 to 49 microg per day, slowed neurodegeneration, and prolonged life.”

    Animalsin NPC1 mice

    Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse

    The Journal of neuroscience : the official journal of the Society for Neuroscience26 Dec 2007

Cholesterol excretion

upin mice1

1 study

  1. Liver x receptor agonist increases cholesterol excretion in mice (from 17 to 49 microg per day).

    “Treatment with this LXR agonist increased cholesterol excretion out of brain from 17 to 49 microg per day”

    Animalsin NPC1 micebrain

    Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse

    The Journal of neuroscience : the official journal of the Society for Neuroscience26 Dec 2007

More on Cholesterol excretion

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