C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
1 lab in 1 country
Humans1
Animals1
Outcomes
2
Inflammation
↓downin rats1
1 study
Linoleic acid decreases inflammation in rats.
“After treatment with LA significant (p ≤ 0.05) increase in the level of FRAP, PMRS, GSH, SOD and CAT was reported and a significant decrease in the level of ROS, MDA, PCO, AOPP and inflammatory cytokines.”
Animalsin aging ratsblood5 mg/kg body weight28 daysmalesn = 6
Linoleic acid decreases oxidative stress and ROS signalling in rats.
“After treatment with LA significant (p ≤ 0.05) increase in the level of FRAP, PMRS, GSH, SOD and CAT was reported and a significant decrease in the level of ROS, MDA, PCO, AOPP and inflammatory cytokines.”
Animalsin aging ratsblood5 mg/kg body weight28 daysmalesn = 6
The relative rate of new peripheral artery disease was 0.75 for the highest versus lowest fifth of linoleic acid levels.The relative rate of new peripheral artery disease was 0.75 for the highest versus lowest fifth of linoleic acid levels.
Mexican adults with the highest levels of non-DHA omega-3 fats had a 20% lower hazard of death than those with the lowest.Mexican adults with the highest levels of non-DHA omega-3 fats had a 20% lower hazard of death than those with the lowest.