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LINE-1 antisense oligonucleotides

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Cells1

Outcomes

2

Lifespan

upin animals1

1 study

  1. LINE-1 antisense oligonucleotides extend lifespan.

    “systemic delivery of ASOs rescued the histophysiology of tissues and increased the life span of a Hutchinson-Gilford progeria syndrome mouse model.”

    Animalsin a Hutchinson-Gilford progeria syndrome mouse modelantisense oligonucleotides

    LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

    Science translational medicine10 Aug 2022

Epigenetic age

downin cells1

1 study

  1. LINE-1 antisense oligonucleotides decrease epigenetic age in cells.

    “reversed DNA methylation age, and counteracted the expression of senescence-associated secretory phenotype genes”

    Cellsin dermal fibroblast cells from patients with different progeroid syndromesantisense oligonucleotides

    LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes

    Science translational medicine10 Aug 2022

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