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Limosilactobacillus fermentum + lactococcus lactis

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Harbin Institute of Technology and 1 more
  • Animals1

Outcomes

5

Acetic acid and butyric acid production

upin mice1

1 study

  1. Limosilactobacillus fermentum + lactococcus lactis increases acetic acid and butyric acid production in mice.

    “thereby increasing the acetic acid and butyric acid production.”

    Animalsmixture of TD-3 and MQ1-1 strainsintestine

    Qula-derived Limosilactobacillus fermentum TD-3 and Lactococcus lactis MQ1-1 alleviate aging-related intestinal barrier dysfunction via microbiota-short-chain fatty acid-AMPK/MLCK-tight junction axis

    Journal of dairy science28 Aug 2025

Inflammation

downin mice1

1 study

  1. Limosilactobacillus fermentum + lactococcus lactis decreases inflammation in mice.

    “PM decreased colon oxidative stress (SOD, GSH-Px, and malondialdehyde) and inflammation (IL-6, IL-1β, TNFα, and IL-10)”

    Animalsmixture of TD-3 and MQ1-1 strainscolon

    Qula-derived Limosilactobacillus fermentum TD-3 and Lactococcus lactis MQ1-1 alleviate aging-related intestinal barrier dysfunction via microbiota-short-chain fatty acid-AMPK/MLCK-tight junction axis

    Journal of dairy science28 Aug 2025

More on Inflammation

Oxidative stress and ROS signalling

downin mice1

1 study

  1. Limosilactobacillus fermentum + lactococcus lactis decreases oxidative stress and ROS signalling in mice.

    “PM decreased colon oxidative stress (SOD, GSH-Px, and malondialdehyde)”

    Animalsmixture of TD-3 and MQ1-1 strainscolon

    Qula-derived Limosilactobacillus fermentum TD-3 and Lactococcus lactis MQ1-1 alleviate aging-related intestinal barrier dysfunction via microbiota-short-chain fatty acid-AMPK/MLCK-tight junction axis

    Journal of dairy science28 Aug 2025

More on Oxidative stress and ROS signalling

AMPK signalling

upin mice1

1 study

  1. Limosilactobacillus fermentum + lactococcus lactis activates AMPK signalling in mice.

    “the combination of Lb. fermentum TD-3 and Lc. lactis MQ1-1 activated the AMPK signaling pathway by regulating the gut microbiota and metabolites.”

    Animalsmixture of TD-3 and MQ1-1 strainsintestine

    Qula-derived Limosilactobacillus fermentum TD-3 and Lactococcus lactis MQ1-1 alleviate aging-related intestinal barrier dysfunction via microbiota-short-chain fatty acid-AMPK/MLCK-tight junction axis

    Journal of dairy science28 Aug 2025

More on AMPK signalling

Intestinal barrier integrity

upin mice1

1 study

  1. Limosilactobacillus fermentum + lactococcus lactis improves intestinal barrier integrity in mice.

    “the combination of probiotic mixture (PM) of Lb. fermentum TD-3 and Lc. lactis MQ1-1 enhanced intestinal barrier integrity”

    Animalsmixture of TD-3 and MQ1-1 strainsintestine

    Qula-derived Limosilactobacillus fermentum TD-3 and Lactococcus lactis MQ1-1 alleviate aging-related intestinal barrier dysfunction via microbiota-short-chain fatty acid-AMPK/MLCK-tight junction axis

    Journal of dairy science28 Aug 2025

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