L-kynurenine

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Institutes of Health

Animals1

Outcomes

Frailty

upin mice1+17%

1 study

L-kynurenine increases frailty in mice (+17%).
“Correspondingly, L-Kyn increased frailty prevalence in male (+17%) and female (+26%) wildtype mice (p = 0.025 and 0.0001 respectively)”
Animalswildtype micemales
Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice
Journal of cachexia, sarcopenia and muscle1 Feb 2026

Walking speed

downin mice1

1 study

L-kynurenine impairs walking speed in mice.
“A main effect of L-Kyn diet for decreasing maximal walking speed only was found in female mice (p = 0.037).”
Animalswildtype micefemales
Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice
Journal of cachexia, sarcopenia and muscle1 Feb 2026

Treadmill endurance capacity

downin mice1

1 study

L-kynurenine impairs treadmill endurance capacity in mice.
“A main effect of L-Kyn diet was observed for decreasing treadmill endurance capacity and daily physical activity in male mice (p ≦ 0.002).”
Animalswildtype micemales
Elevating Circulating L-Kynurenine Promotes Frailty in Aging Mice
Journal of cachexia, sarcopenia and muscle1 Feb 2026