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Kukoamine a

Intervention

1 paper5 findings

PubChem 5318865ChEBI 81220

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Kentucky Legislative Research Commission and 1 more
  • Model organisms1

Outcomes

5

Heat stress-induced mobility impairment

downin worms1

1 study

  1. Kukoamine a prevents heat stress-induced mobility impairment in worms.

    “Furthermore, it prevented heat stress-induced mobility impairment.”

    Model organismsheat stress

    Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins

    Journal of ethnopharmacology22 Aug 2025

Expression of hsf-1, hsp-6, HSP-4 and hsp-16.2

upin worms1

1 study

  1. Kukoamine a increases expression of hsf-1, hsp-6, HSP-4 and hsp-16.2 in worms.

    “The treatment significantly increased the expression of HSF-1, as well as its downstream targets, HSP-6, HSP-4, and HSP-16.2”

    Model organisms

    Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins

    Journal of ethnopharmacology22 Aug 2025

More on Expression of hsf-1, hsp-6, HSP-4 and hsp-16.2

Reactive oxygen species

downin worms1

1 study

  1. Kukoamine a decreases reactive oxygen species in worms.

    “Furthermore, it attenuated the age-associated increase in ROS levels.”

    Model organisms

    Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins

    Journal of ethnopharmacology22 Aug 2025

More on Reactive oxygen species

Muscle mitochondrial morphology

upin worms1

1 study

  1. Kukoamine a improves muscle mitochondrial morphology in worms.

    “KA treatment ameliorated the age-related decrease in swimming activity and preserved muscle mitochondrial morphology in aged worms.”

    Model organismsmuscle

    Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins

    Journal of ethnopharmacology22 Aug 2025

Swimming activity

upin worms1

1 study

  1. Kukoamine a improves swimming activity in worms.

    “KA treatment ameliorated the age-related decrease in swimming activity and preserved muscle mitochondrial morphology in aged worms.”

    Model organisms

    Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins

    Journal of ethnopharmacology22 Aug 2025

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