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KF4

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Alpha-1 Foundation and 7 more
  • Animals1

Outcomes

1

Emphysema

downin mice1

1 study

  1. KF4 prevents emphysema in mice.

    “5 mg/kg weekly prevented emphysema in the PPE model with both pre- and postinjury initiation and in the CS model.”

    Animalslung5 mg/kg weekly

    Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling

    JCI insight9 Jan 2024

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