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CELA1

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Alpha-1 Foundation and 7 more
  • Animals1

Effects

2

Elastin

downin mice1

1 study

  1. CELA1 decreases elastin in mice.

    “In all 3 models, Cela1-/- mice had less emphysema and preserved lung elastin despite increased lung immune cells.”

    Animalsin PPE, cigarette smoke, and aging modelslung

    Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling

    JCI insight9 Jan 2024

More on Elastin

Emphysema

upin mice1

1 study

  1. CELA1 increases emphysema in mice.

    “In all 3 models, Cela1-/- mice had less emphysema and preserved lung elastin despite increased lung immune cells.”

    Animalsin PPE, cigarette smoke, and aging modelslung

    Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling

    JCI insight9 Jan 2024

More on Emphysema

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