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KF-8

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Distinguished Young Scholar Foundation of Hunan Province and 3 more
  • Animals1

Outcomes

2

Inflammation

downin mice1

1 study

  1. KF-8 decreases inflammation in mice.

    “KF-8 and AKK synergistically attenuated pro-inflammatory pathways, particularly TNF-α, in the blood and in the hippocampus.”

    Animalsin aged mice

    TNF-α modulation by rice bran peptides: implications for gut microbiota stability and cognitive health in aging

    NPJ biofilms and microbiomes9 Oct 2025

More on Inflammation

Cognitive function

upin mice1

1 study

  1. KF-8 improves cognitive function in mice.

    “KF-8 was shown to ameliorate age-related traits in aged mice by reshaping gut microbiota, notably by stabilizing Akkermansia muciniphila (AKK), to suppress systemic inflammation and cognitive deficits.”

    Animalsin aged mice

    TNF-α modulation by rice bran peptides: implications for gut microbiota stability and cognitive health in aging

    NPJ biofilms and microbiomes9 Oct 2025

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