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Isodgr-neutralizing antibody

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Brock University and 4 more
  • Animals1

Outcomes

1

Blood-brain barrier integrity

upin mice1

1 study

  1. Isodgr-neutralizing antibody improves blood-brain barrier integrity in mice.

    “systemic treatment with an isoDGR-neutralizing antibody largely prevented capillary breaches and leakage, and even restored barrier integrity in aged wild-type mice.”

    Animalswild-type micebrain

    IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown

    bioRxiv (Cold Spring Harbor Laboratory)14 Jul 2025Preprint

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