INTERLEUKIN-2

1. INTERLEUKIN-2 decreases cellular senescence in human cells.

   “In vitro, IL-2 downregulated ELF3 expression, suppressing the NF-κB pathway and attenuating cellular senescence.”

   Cellshigh glucosecornea

   ELF3 promotes hyperglycemia-induced corneal epithelial senescence and IL-2 attenuates ELF3-associated signaling

   Frontiers in molecular biosciences·24 Jun 2026

More on Cellular senescence

1. INTERLEUKIN-2 improves corneal epithelial wound healing in mice.

   “In diabetic mice, topical IL-2 application reduced ELF3 levels, decreased senescence markers, and accelerated corneal epithelial wound healing.”

   Animalshyperglycemiacornea

   ELF3 promotes hyperglycemia-induced corneal epithelial senescence and IL-2 attenuates ELF3-associated signaling

   Frontiers in molecular biosciences·24 Jun 2026

1. INTERLEUKIN-2 improves depressive symptoms in humans.

   “correction of immune senescent macrophages and T cell system by anti-inflammatory agents and low dose IL-2 treatment has antidepressant effects”

   Reviewin MDD patientslow dose

   Stress, the immune system and depression

   Nederlands tijdschrift voor geneeskunde·20 Dec 2023