INTERLEUKIN-16
- 3 independent labs in 2 countries
- Funders: National Institute of General Medical Sciences and 5 more
- Humans2
- Cells1
Outcomes
4Muscle mass
downin mice1
1 study
Muscle mass
downin mice1
INTERLEUKIN-16 decreases muscle mass in mice.
“The mice treated with IL-16 showed significantly impaired muscle function and physical performance and loss of muscle mass.”
Animalsskeletal muscle
Role of IL-16 in age-related skeletal muscle atrophy: an integrated study
BMC musculoskeletal disordersApr 17, 2025
Muscle function
downin mice1
1 study
Muscle function
downin mice1
INTERLEUKIN-16 impairs muscle function in mice.
“The mice treated with IL-16 showed significantly impaired muscle function and physical performance and loss of muscle mass.”
Animals
Role of IL-16 in age-related skeletal muscle atrophy: an integrated study
BMC musculoskeletal disordersApr 17, 2025
LINE-1 RNA
upin human cells1
1 study
LINE-1 RNA
upin human cells1
INTERLEUKIN-16 increases LINE-1 RNA in human cells.
“a short-term 24-hour exposure to recombinant human IL16 was sufficient to transiently induce subtle, but widespread, upregulation of L1 subfamilies.”
Cellslymphoblastoid cells24-hour
An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells
PLoS geneticsJun 7, 2024
Grip strength
downin humans1
1 study
Grip strength
downin humans1
INTERLEUKIN-16 impairs grip strength in humans (0.977 [0.956-0.998] for EWGSOP).
“IL16 was causally associated with hand grip strength (0.977 [0.956-0.998] for EWGSOP and 0.933 [0.874-0.996] for FNIH)”
Humans
Journal of cachexia, sarcopenia and muscleMar 31, 2024