Intellectual activities

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Bundesministerium für Bildung und Forschung and 6 more

Humans2

Associations

Numeracy

upin humans1

1 study

Intellectual activities are associated with numeracy in humans.
“Intellectual activities were positively associated with numeracy across groups, with the largest effects observed in dementia.”
HumansAcross diagnostic groups; largest associations in dementian = 17,105
Differential Effects of Lifestyle Indicators on Cognitive Functioning Across Healthy, Dementia, Parkinson's Disease, and Stroke Groups
Journal of clinical medicine30 Mar 2026

Persistently low intrinsic capacity trajectory

downin humans1OR 0.37

1 study

Intellectual activities are associated with persistently low intrinsic capacity trajectory in humans (OR 0.37, 95% CI 0.26–0.53).
“more frequent engagement in intellectual activities (OR 0.37, 95% CI 0.26-0.53) and social activities (OR 0.36, 95% CI 0.25-0.51) was associated with a reduced likelihood”
HumansAdjusted for sociodemographic factorsn = 1,344
Associations between leisure activities with trajectories of intrinsic capacity among Chinese older adults: the China health and retirement longitudinal study
Archives of public health = Archives belges de sante publique23 Jun 2025