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Insulin/igf-1 signaling inhibitor

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fundação para a Ciência e a Tecnologia and 3 more
  • Model organisms1

Outcomes

1

Machado-Joseph disease

downin worms1

1 study

  1. Insulin/igf-1 signaling inhibitor protects against Machado-Joseph disease in worms.

    “The therapeutic value of the insulin/IGF-1 downregulation was demonstrated through the chronic treatment of the SCA3/MJD model with an insulin/IGF-1 signaling inhibitor”

    Model organismsin a Caenorhabditis elegans model of MJD/SCA3chronic

    Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3

    Mechanisms of ageing and development24 Apr 2025

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