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Machado-Joseph disease

Disease

1 paper1 finding

MeSH

  • Model organisms1

Interventions

1

Insulin/igf-1 signaling inhibitor

downin worms1

1 study

  1. Insulin/igf-1 signaling inhibitor protects against Machado-Joseph disease in worms.

    “The therapeutic value of the insulin/IGF-1 downregulation was demonstrated through the chronic treatment of the SCA3/MJD model with an insulin/IGF-1 signaling inhibitor”

    Model organismsin a Caenorhabditis elegans model of MJD/SCA3chronic

    Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3

    Mechanisms of ageing and development24 Apr 2025

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