Inhibition of systemic inflammation
Inhibition of systemic inflammation has been studied in 2 papers since 2024: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Jun 30, 2025: “Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis”.
2 papers study it5 findingsUpdated
- 1 lab in 1 country
- Funders: National Institute on Aging and others
- Animals2
What did studies of Inhibition of systemic inflammation find?
4Studies of Inhibition of systemic inflammation measured 4 outcomes; the most studied are ferroptosis (2 studies), physical function (1) and strength recovery (1).
Ferroptosis
downin mice2
2 studies
Ferroptosis
downin mice2
Inhibition of systemic inflammation prevents ferroptosis in mice.
“long-term inhibition of systemic inflammation that is initiated at 12 months of age effectively prevents ferroptosis”
Animalsskeletal musclelong-term
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Nature aging
Inhibition of systemic inflammation prevents ferroptosis in mice.
“Implementing preventative strategies to inhibit systemic inflammation prevented aged MuSC ferroptosis”
Animalsin aged MuSCs
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Research squarePreprint
Physical function
upin mice1
1 study
Physical function
upin mice1
Inhibition of systemic inflammation improves physical function in mice.
“preserves MuSC numbers and enhances muscle regeneration and functional recovery”
Animalsskeletal musclelong-term
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Nature aging
Strength recovery
upin mice1
1 study
Strength recovery
upin mice1
Inhibition of systemic inflammation improves strength recovery in mice.
“significantly enhanced aged muscle regeneration and strength recovery and extended both lifespan and healthspan in mice”
Animalsin aged mice
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Research squarePreprint
Lifespan
upin mice1
1 study
Lifespan
upin mice1
Inhibition of systemic inflammation extends lifespan in mice.
“extended both lifespan and healthspan in mice”
Animalsin aged mice
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Research squarePreprint