KMT5A
- 1 lab in 1 country
- Funders: National Institute on Aging and others
- Animals2
Effects
1Ferroptosis
downin mice1
1 study
Ferroptosis
downin mice1
KMT5A protects against ferroptosis in mice.
“lack of Kmt5a and the subsequent absence of de novoH4K20me1 culminate in cell death by ferroptosis”
Animalsin setting of inflammatory signals or aging
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Research squarePreprint
Upstream
1Inflammation
downin mice1
1 study
Inflammation
downin mice1
Inflammation decreases KMT5A in mice.
“inflammatory signals downregulate Kmt5a, the enzyme responsible for depositing H4K20me1”
Animalsmuscle stem cell
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Nature aging
Latest
Nature Aging
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Experiments in miceFerroptosis
Research Square
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
Preprint: experiments in miceInterventions