Inflammatory stress

Inflammatory stress has been studied in 2 papers since 2025: 1 observational study in people, 1 in cells; 2 in the past year. The newest story, Oct 29, 2026: “Some human blood stem cells remember inflammation in mice”.

Exposure

2 papers study it3 findingsUpdated

See all 2

None of its findings points the other way.

  • 2 independent labs in 2 countries
  • Funders: National Institute of Diabetes and Digestive and Kidney Diseases and 8 more
  • 1 of 2 findings with company ties
  • Humans1
  • Cells1

What did studies of Inflammatory stress find?

3

Studies of Inflammatory stress measured 3 outcomes; the most studied are hematopoietic output (1 study), competitive advantage (1) and yellow marrow (1).

Hematopoietic output

downin humans1

1 study
  1. Inflammatory stress decreases hematopoietic output in xenograft models.

    “The HSC-iM subset exhibited quiescence and restrained haematopoietic output.”

    Animalsin xenograft models

    Some human blood stem cells remember inflammation in mice

    Nature

Competitive advantage

upin human cells1

1 study
  1. Inflammatory stress increases competitive advantage in p53 mutant HSPCs.

    “inflammatory stress confers a competitive advantage to p53 mutant hematopoietic stem and progenitor cells (HSPCs)”

    Cellsin p53 mutant HSPCs

    Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment

    The Journal of clinical investigation

Yellow marrow

upin mice1

1 study
  1. Inflammatory stress induces yellow marrow in mice.

    “Many rounds of inflammatory stress induced yellow marrow in mice.”

    Reviewbone marrow

    Bone marrow niches for hematopoietic stem cells in homeostasis and aging

    Experimental hematology

Funding

3 grants since 2018

National Institute of Diabetes and Digestive and Kidney DiseasesUS$753.7kUKRI | Medical Research Council

Latest

Nov 2025: 0Dec 2025: 1Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 1Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 02 papers in 12 months
Nature

Some human blood stem cells remember inflammation in mice

Experiments with human cord blood cells from 62 donors identified a less active stem-cell subset that retained molecular changes after inflammation in mice.Experiments with human cord blood cells from 62 donors identified a less active stem-cell subset that retained molecular changes after inflammation in mice.

Animal study · 62 animalsInflammation