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Hypothermic crystalloid perfusion

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Deutsche Forschungsgemeinschaft and 1 more
  • Animals1

Outcomes

2

Senescence-associated secretory phenotype (SASP)

downin pigs1

1 study

  1. Hypothermic crystalloid perfusion inhibits senescence-associated secretory phenotype (SASP) in pigs.

    “HCP resulted in the downregulation of genes involved in NF-κB-, STAT3-, and SASP-activation and inflammation”

    Animalsin DCD heartsheart4 h

    Transcriptomic Changes in the Myocardium and Coronary Artery of Donation after Circulatory Death Hearts following Ex Vivo Machine Perfusion

    International journal of molecular sciences19 Jan 2024

More on Senescence-associated secretory phenotype (SASP)

NF-κB signalling

downin pigs1

1 study

  1. Hypothermic crystalloid perfusion inhibits NF-κB signalling in pigs.

    “HCP resulted in the downregulation of genes involved in NF-κB-, STAT3-, and SASP-activation and inflammation”

    Animalsin DCD heartsheart4 h

    Transcriptomic Changes in the Myocardium and Coronary Artery of Donation after Circulatory Death Hearts following Ex Vivo Machine Perfusion

    International journal of molecular sciences19 Jan 2024

More on NF-κB signalling

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