Hydroxysafflor yellow a

3 papers9 findings

PubChem 6443665 ChEBI 139030 MeSH C085278

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: National Natural Science Foundation of China and 3 more

Model organisms1
Cells2

Outcomes

Oxidative stress and ROS signalling

downin human cells2

2 studies

Hydroxysafflor yellow a decreases oxidative stress and ROS signalling in human cells.
“Furthermore, HSYA significantly attenuated intracellular reactive oxygen species (ROS) accumulation.”
Cellsin senescent hUC-MSCs
Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway
International journal of molecular sciences1 Oct 2025
Hydroxysafflor yellow a decreases oxidative stress and ROS signalling in human cells.
“inhibited telomere attrition, reduced the ROS accumulation, increased mitochondrial membrane potential in senescent cells.”
Cellsin replicative senescent hUC-MSCs0.01 mg/ml
Hydroxysafflor Yellow A Ameliorates the Replicative Senescence of Human Umbilical Cord Mesenchymal Stem Cells by Suppressing Oxidative Stress
Zhongguo shi yan xue ye xue za zhi1 Oct 2025

More on Oxidative stress and ROS signalling

Paralysis

downin worms1

1 study

Hydroxysafflor yellow a decreases paralysis in worms.
“Importantly, HSYA alleviated toxic protein aggregation in Alzheimer's- and Parkinson's-like worm models, delaying paralysis and supporting neuronal health.”
Model organismsin Alzheimer's- and Parkinson's-like worm models
Hydroxysafflor yellow A from safflower enhances stress resilience and proteostasis in Caenorhabditis elegans
Food research international (Ottawa, Ont.)20 Dec 2025

Protein aggregation

downin worms1

1 study

Hydroxysafflor yellow a decreases protein aggregation in worms.
“Importantly, HSYA alleviated toxic protein aggregation in Alzheimer's- and Parkinson's-like worm models, delaying paralysis and supporting neuronal health.”
Model organismsin Alzheimer's- and Parkinson's-like worm models
Hydroxysafflor yellow A from safflower enhances stress resilience and proteostasis in Caenorhabditis elegans
Food research international (Ottawa, Ont.)20 Dec 2025

Lifespan

upin worms1+8.5%

1 study

Hydroxysafflor yellow a extends lifespan in worms (8.49%).
“HSYA significantly extended lifespan by up to 78 % under heat stress, 29.03 % under oxidative stress, and also 8.49 % under normal conditions.”
Model organismsnormal conditions
Hydroxysafflor yellow A from safflower enhances stress resilience and proteostasis in Caenorhabditis elegans
Food research international (Ottawa, Ont.)20 Dec 2025

CDKN2A

downin human cells1

1 study

Hydroxysafflor yellow a decreases CDKN2A in human cells.
“Additionally, HSYA downregulated the expression of p53 and p16, and upregulated the expression of OCT4. HSYA decreased p16 protein level and increased OCT4 and SOX2 protein levels.”
Cellsin replicative senescent hUC-MSCs0.01 mg/ml
Hydroxysafflor Yellow A Ameliorates the Replicative Senescence of Human Umbilical Cord Mesenchymal Stem Cells by Suppressing Oxidative Stress
Zhongguo shi yan xue ye xue za zhi1 Oct 2025