Human umbilical cord mesenchymal stem cell-derived exosomes

1. Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ferroptosis in mice.

   Animalshuman umbilical cord mesenchymal stem cell-derived exosomesovary240 μL/dose, 6.5 × 1010 particles/mL2 weeksfemalesn = 8

   Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis · Reproduction (Cambridge, England) · 26 Aug 2026

2. Human umbilical cord mesenchymal stem cell-derived exosomes inhibit ferroptosis in mice.

   “hUCMSC-exos inhibited ferroptosis by reducing divalent iron ions and malondialdehyde levels, increasing the glutathione/oxidized glutathione ratio, and upregulating glutathione peroxidase 4 expression.”

   Animalsnatural agingkidneyn = 20

   Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation · GSA 2025 abstract · 31 Dec 2025

Ferroptosis →

1. Human umbilical cord mesenchymal stem cell-derived exosomes activate NRF2–KEAP1 antioxidant response in mice.

   Animalshuman umbilical cord mesenchymal stem cell-derived exosomesovary240 μL/dose, 6.5 × 1010 particles/mL2 weeksfemalesn = 8

   Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis · Reproduction (Cambridge, England) · 26 Aug 2026

NRF2–KEAP1 antioxidant response →

1. Human umbilical cord mesenchymal stem cell-derived exosomes improve oocyte yield in mice.

   Animalshuman umbilical cord mesenchymal stem cell-derived exosomesovary240 μL/dose, 6.5 × 1010 particles/mL2 weeksfemalesn = 8

   Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis · Reproduction (Cambridge, England) · 26 Aug 2026

1. Human umbilical cord mesenchymal stem cell-derived exosomes decrease genomic stress in mice.

   Animalshuman umbilical cord mesenchymal stem cell-derived exosomesovary240 μL/dose, 6.5 × 1010 particles/mL2 weeksfemalesn = 8

   Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis · Reproduction (Cambridge, England) · 26 Aug 2026

1. Human umbilical cord mesenchymal stem cell-derived exosomes increase primary and antral follicles in mice.

   Animalshuman umbilical cord mesenchymal stem cell-derived exosomesovary240 μL/dose, 6.5 × 1010 particles/mL2 weeksfemalesn = 8

   Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis · Reproduction (Cambridge, England) · 26 Aug 2026

1. Human umbilical cord mesenchymal stem cell-derived exosomes decrease senescence-associated beta-galactosidase in mice.

   “Aging markers (SA-β-Gal, p16INK4a, and γH2AX) were downregulated in the hUCMSC-exos group.”

   Animalsnatural agingkidneyn = 20

   Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation · GSA 2025 abstract · 31 Dec 2025

Senescence-associated beta-galactosidase →

1. Human umbilical cord mesenchymal stem cell-derived exosomes decrease creatinine in mice.

   “hUCMSC-exos significantly reduced blood urea nitrogen, creatinine, and uric acid levels compared to the natural aging group (P < 0.01).”

   Animalsnatural agingwhole-bloodn = 20

   Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation · GSA 2025 abstract · 31 Dec 2025

Creatinine →

1. Human umbilical cord mesenchymal stem cell-derived exosomes decrease blood urea nitrogen in mice.

   “hUCMSC-exos significantly reduced blood urea nitrogen, creatinine, and uric acid levels compared to the natural aging group (P < 0.01).”

   Animalsnatural agingwhole-bloodn = 20

   Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation · GSA 2025 abstract · 31 Dec 2025

Blood urea nitrogen →