Metabolomics Reveals Exosome Protection in Aging Mouse Kidneys via Ferroptosis Alleviation
GSA 2025 Abstract
Abstract
This study evaluated the effects of human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-exos) on renal function in naturally aging mice and explored underlying mechanisms. Twenty-four-month-old C57BL/6J mice were divided into a natural aging group (WT-AC, n = 10) and an hUCMSC-exos intervention group (WT-AEX, n = 10).
- Human umbilical cord mesenchymal stem cell-derived exosomes
- Ferroptosis
- Cellular senescence
- Acute kidney injury
- Blood urea nitrogen
- Mice
