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Htert mrna lnp

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Cancer Prevention and Research Institute of Texas and 1 more
  • Animals1

Outcomes

5

DNA damage response

downin mice1

1 study

  1. Htert mrna lnp decreases DNA damage response in mice.

    “while reducing cellular senescence (p21) and DNA damage (53BP1)”

    Animalsmouse modelskin

    Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

    Advanced healthcare materialsAug 25, 2023

More on DNA damage response

Cellular senescence

downin mice1

1 study

  1. Htert mrna lnp decreases cellular senescence in mice.

    “while reducing cellular senescence (p21) and DNA damage (53BP1)”

    Animalsmouse modelskin

    Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

    Advanced healthcare materialsAug 25, 2023

More on Cellular senescence

Cell proliferation

upin mice1

1 study

  1. Htert mrna lnp increases cell proliferation in mice.

    “increasing hSCS engraftment (Lamin) and proliferation (Ki67)”

    Animalsmouse modelskin

    Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

    Advanced healthcare materialsAug 25, 2023

Engraftment

upin mice1

1 study

  1. Htert mrna lnp increases engraftment in mice.

    “increasing hSCS engraftment (Lamin) and proliferation (Ki67)”

    Animalsmouse modelskin

    Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

    Advanced healthcare materialsAug 25, 2023

Telomerase activity

upin human cells1

1 study

  1. Htert mrna lnp increases telomerase activity in human cells.

    “Telomerase activity in hSCS is significantly increased.”

    Cellsin hSCS

    Telomerase mRNA Enhances Human Skin Engraftment for Wound Healing

    Advanced healthcare materialsAug 25, 2023

More on Telomerase activity

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