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Histamine-2 receptor antagonists

Histamine-2 receptor antagonists has been studied in 11 papers since 2021: 6 observational studies in people, 5 reviews; 4 in the past year. The newest story, Oct 26, 2026: “Proton pump inhibitors linked to more deaths in heart failure”.

Intervention

11 papers study it9 findingsUpdated

2 new papers in 30 daysSee all 11 papers on histamine-2 receptor antagonists

At a glance

The findings reach people, from one lab or study. 6 independent labs in 4 countries.

“use of H2RAs was not related to the risk of ASCVD (HR: 0.97, 95% CI: 0.85-1.11).”
Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adultsAtherosclerosis2022doi:10.1016/j.atherosclerosis.2022.09.001

1 of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 6 independent labs in 4 countries
  • 1 finding against
  • Funders: Ministry of Education of China and 6 more
  • Humans6

What did studies of histamine-2 receptor antagonists find?

3

Studies of histamine-2 receptor antagonists measured 3 outcomes: atherosclerotic cardiovascular disease, dementia and bone mineral density.

Atherosclerotic cardiovascular disease

no changein humans1HR 0.97

1 study

  1. Histamine-2 receptor antagonists were not clearly linked with atherosclerotic cardiovascular disease in humans (without cardiovascular diseases or anti-hypertensive treatment at baseline) (HR 0.97, 95% CI 0.85-1.11).

    “use of H2RAs was not related to the risk of ASCVD (HR: 0.97, 95% CI: 0.85-1.11).”

    Humanswithout cardiovascular diseases or anti-hypertensive treatment at baselinemedian of 12.5 yearsn = 316,730

    Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults

    Atherosclerosis

More on Atherosclerotic cardiovascular disease

Dementia

no changein humans1HR 1.2

1 study

  1. Histamine-2 receptor antagonists showed no clear effect on dementia in humans (HR 1.20 (95% CI: 0.98-1.47)).

    “H2RA use was not associated with the risk of dementia, as indicated by the pooled HR of 1.20 (95% CI: 0.98-1.47).”

    Review

    No association between acid suppressant use and risk of dementia: an updated meta-analysis

    European journal of clinical pharmacology

More on Dementia

Bone mineral density

no changein humans1

1 study

  1. Histamine-2 receptor antagonists were not clearly linked with bone mineral density in humans.

    “There is no significant association between long-term H2RA use and lumber spine BMD.”

    Humanslumbar spinelong-term

    Prolonged Use of Proton Pump Inhibitors, but Not Histamine-2 Receptor Antagonists, Is Associated With Lower Bone Mineral Density in Males Aged Over 70

    Frontiers in medicine

What is histamine-2 receptor antagonists linked with?

6

Studies link histamine-2 receptor antagonists with 6 measures, among them dementia, mortality and cardiovascular events.

Dementia

upin humans1HR 1.44

1 study

  1. Histamine-2 receptor antagonists are associated with dementia in humans (Post hoc analysis) (HR 1.44, 95% CI 1.07–1.93).

    “In a post hoc analysis, H2RA use itself was associated with dementia (HR = 1.44, 95% CI 1.07-1.93)”

    ReviewPost hoc analysis

    Evaluating the Association Between PPI Use and Dementia Risk Considering Methodological Choices: An Updated Meta-Analysis

    Clinical pharmacology and therapeutics

More on Dementia

Mortality

upin humans1HR 1.11

1 study

  1. Histamine-2 receptor antagonists are associated with mortality in humans (Heart failure; compared with non-initiators) (2.99 more deaths per 100 patients; HR 1.11, 95% CI 1.07-1.14).

    “but a modest increase in all-cause mortality (2.99 more deaths per 100 patients; HR 1.11, 95% CI 1.07-1.14)”

    HumansHeart failure; compared with non-initiatorsFive years

    Proton pump inhibitors linked to more deaths in heart failure

    ESC Congress 2026 abstract

Cardiovascular events

downin humans1HR 0.93

1 study

  1. Histamine-2 receptor antagonists are associated with cardiovascular events in humans (Heart failure; compared with non-initiators) (9.17 fewer events per 100 patients; HR 0.93, 95% CI 0.90-0.97).

    “H2RA use was linked to 9.17 fewer CVD events (HR 0.93, 95% CI 0.90-0.97)”

    HumansHeart failure; compared with non-initiatorsFive years

    Proton pump inhibitors linked to more deaths in heart failure

    ESC Congress 2026 abstract

Ovarian cancer

downin humans1

1 study

  1. Histamine-2 receptor antagonists are linked with a lower risk of ovarian cancer in humans (aOR 0.78).

    “H2RA use was associated with reduced risks of cervical (aOR 0.80), endometrial (0.68), and ovarian cancers (0.78).”

    Humans>60 days within two yearsfemales

    The Potential Impact of Histamine-2 Receptor Antagonists on Gynecologic Cancer Risk: A Population-Based Study of 23 Million Individuals

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Ovarian cancer

Endometrial cancer

downin humans1

1 study

  1. Histamine-2 receptor antagonists are linked with a lower risk of endometrial cancer in humans (aOR 0.68).

    “H2RA use was associated with reduced risks of cervical (aOR 0.80), endometrial (0.68), and ovarian cancers (0.78).”

    Humans>60 days within two yearsfemales

    The Potential Impact of Histamine-2 Receptor Antagonists on Gynecologic Cancer Risk: A Population-Based Study of 23 Million Individuals

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Endometrial cancer

Cervical cancer

downin humans1

1 study

  1. Histamine-2 receptor antagonists are linked with a lower risk of cervical cancer in humans (aOR 0.80).

    “H2RA use was associated with reduced risks of cervical (aOR 0.80), endometrial (0.68), and ovarian cancers (0.78).”

    Humans>60 days within two yearsfemales

    The Potential Impact of Histamine-2 Receptor Antagonists on Gynecologic Cancer Risk: A Population-Based Study of 23 Million Individuals

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

More on Cervical cancer

Latest

Dec 2025: 0Jan 2026: 2Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 2Nov 2026: 04 papers in 12 months
ESC Congress 2026 Abstract

Proton pump inhibitors linked to more deaths in heart failure

Starting these drugs was associated with 6.66 more cardiovascular events and 5.74 more deaths per 100 patients over five years than not starting acid-suppressing drugs.Starting these drugs was associated with 6.66 more cardiovascular events and 5.74 more deaths per 100 patients over five years than not starting acid-suppressing drugs.

Cohort · 66,834 peopleHeart failure
Paper

See all 11 papers on histamine-2 receptor antagonists

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