Hindlimb unloading

Exposure

1 paper2 findings

  • 1 lab in 1 country
  • Funders: Canadian Institutes of Health Research and 3 more
  • Animals1

Outcomes

2

Bone strength

downin mice1

1 study
  1. Hindlimb unloading decreases bone strength in mice.

    “HLU demonstrating an intermediate phenotype in bone strength compared to aging.”

    Animalsfemurthree weeksfemales

    Hindlimb unloading results in accelerated bone loss compared to aging in select bone compartments of female murine femurs

    Journal of biomechanics16 Dec 2025

Bone marrow adiposity

upin mice1

1 study
  1. Hindlimb unloading increases bone marrow adiposity in mice.

    “there was a significantly higher level of bone marrow adiposity after HLU greater than aging.”

    Animalsfemurthree weeksfemales

    Hindlimb unloading results in accelerated bone loss compared to aging in select bone compartments of female murine femurs

    Journal of biomechanics16 Dec 2025

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