Hematopoietic stem cell transplantation

Intervention2 papers2 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

2 independent labs in 1 country69 trials, 3 with no results posted

Funders: National Natural Science Foundation of China and 3 more

Humans1
Animals1

Outcomes

Recent thymic emigrant

upin mice1

1 study

Hematopoietic stem cell transplantation increases recent thymic emigrant in mice.
Animalspost-HSCT regeneration via thymus-dependent pathway
Single-cell mapping of thymus-dependent naïve t-cell regeneration reveals CD61-associated states after hematopoietic stem cell transplantation · Experimental hematology & oncology · 2 Sep 2026

Breast cancer

no changein humans1HR 0.93

1 study

Hematopoietic stem cell transplantation has no effect on breast cancer in humans (HR 0.93, 95% CI 0.45-1.94).
HumansHSCT without TBI compared to matched general population controlsfemales
Breast cancer risk among survivors of hematopoietic stem cell transplant with or without total body irradiation: A population-based analysis · Transplantation and cellular therapy · 19 Aug 2026

Breast cancer →

Trials

In trials

Lymphoma
Phase 4 · Status unknown · 7 trials
Leukemia, Myeloid, Acute
Phase 3 · Terminated · 16 trials
Precursor cell lymphoblastic leukemia lymphoma
Phase 3 · Results posted · 9 trials
Leukemia
Phase 3 · Results posted · 8 trials
Neuroblastoma
Phase 3 · Recruiting · 3 trials
Myelodysplastic syndrome
Phase 2/3 · Recruiting · 15 trials

40 of 50

Multiple myeloma
Phase 2/3 · Status unknown · 8 trials
Leukemia, Myelomonocytic, Chronic
Phase 2/3 · Recruiting · 5 trials
Congenital abnormality
Phase 2/3 · Terminated · 1 trial
Sickle Cell Anemia
Phase 2 · Results posted · 7 trials
Graft vs host disease
Phase 2 · Results posted · 6 trials
Hodgkin Disease
Phase 2 · Results posted · 6 trials
Leukemia, Lymphocytic, Chronic, B-Cell
Phase 2 · Results posted · 6 trials
Hematologic neoplasms
Phase 2 · Terminated · 4 trials
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phase 2 · Results posted · 4 trials
non-Hodgkin lymphoma
Phase 2 · Results posted · 4 trials
Plasma Cell Neoplasms
Phase 2 · Results posted · 4 trials
Primary Myelofibrosis
Phase 2 · Recruiting · 4 trials
Follicular lymphoma
Phase 2 · Results posted · 3 trials
Lymphoma, B-Cell, Marginal Zone
Phase 2 · Results posted · 3 trials
Lymphoma, Large B-Cell, Diffuse
Phase 2 · Results posted · 3 trials
Myeloproliferative disorder
Phase 2 · Results posted · 3 trials
Anemia
Phase 2 · Terminated · 2 trials
Anemia, Refractory, with Excess of Blasts
Phase 2 · Recruiting · 2 trials
Aplastic anemia
Phase 2 · Results posted · 2 trials
Fanconi Anemia
Phase 2 · Results posted · 2 trials
Thrombocytopenia
Phase 2 · Terminated · 2 trials
Autoimmune disease
Phase 2 · Results posted · 1 trial
Essential thrombocythemia
Phase 2 · Recruiting · 1 trial
Extranodal NK/T-cell lymphoma
Phase 2 · Results posted · 1 trial
Hematologic disease
Phase 2 · Completed · 1 trial
Infection
Phase 2 · Results posted · 1 trial
Mantle cell lymphoma
Phase 2 · Results posted · 1 trial
Neoplasm
Phase 2 · Completed · 1 trial
Precancerous condition
Phase 2 · Results posted · 1 trial
Recurrence
Phase 2 · Results posted · 1 trial
Sarcoma
Phase 2 · Completed · 1 trial
Systemic lupus erythematosus
Phase 2 · Results posted · 1 trial
Waldenström macroglobulinemia
Phase 2 · Results posted · 1 trial
Leukemia, Biphenotypic, Acute
Phase 1/2 · Recruiting · 2 trials

Stopped

NCT00568633 · Terminated · Leukemia, Myeloid, Acute
Poor accrual
NCT00630565 · Terminated · Congenital abnormality
Slow Accrual
NCT00506948 · Terminated · Graft vs host disease
Halted due to high incidence of veno-oclusive disease of the liver.
NCT03303950 · Terminated · Primary Myelofibrosis
Slow accrual
NCT00424489 · Terminated · Myasthenia gravis
No participants enrolled for more than two years. No plan to continue study.
NCT00278642 · Terminated · Pemphigus
sponsor stopped the study because of lack of elligible participants

All 8

NCT00278486 · Terminated · Retinal disease
First subject over five years after the transplant. The second subject is not in compliance with follow ups. We do not plan to enroll more subjects.
NCT00282412 · Terminated · Rheumatoid arthritis
No participant enrolled for three years. No plan to continue study.