Healthful plant-based diet

6 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

3 independent labs in 3 countries

Funders: Demensfonden and 4 more

Humans5

Associations

Dementia

downin humans2OR 0.976

2 studies

Healthful plant-based diet is associated with dementia in humans (OR 0.976, 95% CI 0.963-0.990).
“hPDI: OR = 0.976, 95% CI = 0.963-0.990”
Humans
Association between plant-based dietary patterns and dementia among Chinese older adults
Frontiers in nutrition21 Nov 2025
Healthful plant-based diet lowers the risk of dementia in humans (HR: 0.39 [95% CI: 0.20-0.74]).
“Dementia risk associated with CMDs was reduced among those with high hPDI (HR: 0.39 [95% CI: 0.20-0.74])”
Humansin older adults with cardiometabolic diseases
Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases
JACC. Advances8 Oct 2025