Unhealthful plant-based diet

7 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

5 independent labs in 4 countries

Funders: National Natural Science Foundation of China and 8 more

Humans6

Outcomes

Biological age

upin humans1

1 study

Unhealthful plant-based diet increases biological age in humans.
“a higher unhealthful plant-based diet index was associated with accelerated biological aging.”
Humans
EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging
npj aging12 Dec 2025

Associations

Dementia

upin humans2OR 1.012

2 studies

Unhealthful plant-based diet is associated with dementia in humans (OR 1.012, 95% CI 1.001-1.024).
“uPDI: OR = 1.012, 95% CI = 1.001-1.024”
Humans
Association between plant-based dietary patterns and dementia among Chinese older adults
Frontiers in nutrition21 Nov 2025
Unhealthful plant-based diet raises the risk of dementia in humans (HR: 3.24 [95% CI: 1.64-6.40]).
“and increased for those with high uPDI (HR: 3.24 [95% CI: 1.64-6.40]).”
Humansin older adults with cardiometabolic diseases
Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases
JACC. Advances8 Oct 2025