GW501516
2 papers study it5 findings
- 2 independent labs in 2 countries
- Funders: Ministry of Science and ICT, South Korea and 4 more
- Cells2
Outcomes
5Endothelial-dependent relaxation
upin animals1
1 study
Endothelial-dependent relaxation
upin animals1
GW501516 improves endothelial-dependent relaxation.
“GYY4137, GW501516 and EMPA preserve endothelial-dependent relaxation (EDR) in D-gal-treated aortae”
Animalsin D-gal-treated aortaeaorta
Acta biochimica et biophysica SinicaAug 16, 2023
SIRT1
upin human cells1
1 study
SIRT1
upin human cells1
GW501516 increases SIRT1 in human cells.
“GW501516 significantly increased the mRNA and protein levels of SIRT1”
Cellsin ARPE-19 cells
Antioxidants (Basel, Switzerland)Jun 20, 2022
DNA damage response
downin human cells1
1 study
DNA damage response
downin human cells1
GW501516 inhibits DNA damage response in human cells.
“GW501516-activated PPARδ almost completely abolished the effects of HG treatment on the formation of phosphorylated H2A histone family member X (γ-H2A.X) foci”
Cellsin high-glucose-treated ARPE-19 cells
Antioxidants (Basel, Switzerland)Jun 20, 2022
Oxidative stress and ROS signaling
downin human cells1
1 study
Oxidative stress and ROS signaling
downin human cells1
GW501516 inhibits oxidative stress and ROS signaling in human cells.
“GW501516-activation of PPARδ suppressed premature senescence and production of reactive oxygen species induced by HG in ARPE-19 cells”
Cellsin high-glucose-induced ARPE-19 cells
Antioxidants (Basel, Switzerland)Jun 20, 2022
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
GW501516 inhibits cellular senescence in human cells.
“GW501516-activation of PPARδ suppressed premature senescence and production of reactive oxygen species induced by HG in ARPE-19 cells”
Cellsin high-glucose-induced ARPE-19 cells
Antioxidants (Basel, Switzerland)Jun 20, 2022