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GW-9662

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • Animals1

Outcomes

2

BCL2

downin rat cells1

1 study

  1. GW-9662 decreases BCL2 in rat cells.

    “GW-9662 also decreased mRNA for bcl-2 on proestrus and diestrus in old and new CL, and on metestrus in new CL.”

    Cellson proestrus and diestrus in old and new CL, and on metestrus in new CLcorpus luteum

    Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat

    Reproduction (Cambridge, England)1 Jan 2007

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Progesterone

no changein rat cells1

1 study

  1. GW-9662 has no effect on progesterone in rat cells.

    “There was no effect of PPARgamma agonists or the antagonist on luteal progesterone production in vitro, or levels of mRNA for 20alpha-HSD.”

    Cellsin vitrocorpora lutea

    Potential role for peroxisome proliferator-activated receptor gamma in regulating luteal lifespan in the rat

    Reproduction (Cambridge, England)1 Jan 2007

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