GTS-21

1 paper1 finding

1 lab in 1 country

Funder: National Natural Science Foundation of China

Humans1

Outcomes

1

Mitochondrial Ca2+ overload

downin cells1

1 study

GTS-21 decreases mitochondrial Ca2+ overload in cells.
“Pharmacological activation of α7nAChR with PNU or GTS-21 restored α7nAChR-VDAC1 coupling, attenuated p66Shc-mediated oxidative stress and reversed mitochondrial Ca2+ overload.”
Cellshyperglycaemic conditions
α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding
Diabetologia15 Dec 2025

Latest

1 in 12 months

Diabetologia15 Dec

α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding

Study in peopleMitochondrion