Growth hormone response to growth hormone-releasing hormone
1 paper studies it1 more mentions it4 findings
- Human trial1
Interventions
2Bromocriptine
no changein humans1
1 study
Bromocriptine
no changein humans1
Bromocriptine has no effect on growth hormone response to growth hormone-releasing hormone in humans.
“Bromocriptine given before GHRH failed to potentiate GHRH action on GH release in either group.”
Human trialBromocriptine pretreatment1.25 mg bromocriptine before 0.5 microgram/kg GHRHmales
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Atenolol
no changein humans1
1 study
Atenolol
no changein humans1
Atenolol has no effect on growth hormone response to growth hormone-releasing hormone in humans.
“Pre-treatment with atenolol before GHRH administration produced no significant increase in peak and AUC GH response in both groups”
Human trialPretreatment before 0.5 microgram/kg GHRHTwo oral doses of 50 mg atenololmales
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Associations
2Growth hormone-releasing hormone
mixedin humans1
1 study
Growth hormone-releasing hormone
mixedin humans1
Growth hormone-releasing hormone is associated with growth hormone response to growth hormone-releasing hormone in humans (One normal response (> 10 ng/ml) after 1 week; one near-normal response (9.7 ng/ml) after 2 weeks; one impaired response (3.2 ng/ml) after 2 weeks).
“One exhibited a normal response (> 10 ng/ml) after 1 week of daily GHRH treatment, another had a near-normal response after 2 weeks (9.7 ng/ml)”
Human trialInitially impaired GH response to intravenous GHRH100 micrograms subcutaneously twice dailyUp to 2 weeksmalesn = 3
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
Older age
downin humans1
1 study
Older age
downin humans1
Older age is associated with growth hormone response to growth hormone-releasing hormone in humans (Peak 3.1 +/- 1.0 versus 21.6 +/- 5.0 ng/ml; AUC 205 +/- 56 versus 1,315 +/- 295 ng/ml/min).
“The elderly men had a significantly lower peak and area under curve (AUC) GH response to intravenous GHRH”
Human trialIntravenous GHRH stimulationD-Ala2 GHRH(1-29)-NH20.5 microgram/kgmalesn = 8
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde