Growth hormone secretion

1. (n-ac-tyr1,d-arg2)ghrh- decreases growth hormone secretion in humans.

   “Graded infusions of GHRH antagonist suppressed GH responses to GHRH in a dose-dependent manner, but with similar potency in both groups.”

   Human trialGHRH-stimulated secretion in healthy mengraded infusionsmales

   In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging

   The Journal of clinical endocrinology and metabolism·Oct 1, 1999

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1. Growth hormone-releasing hormone increases growth hormone secretion in humans.

   “Graded boluses of GHRH elicited dose-dependent GH responses, with no difference between the two age groups.”

   Human trialhealthy mengraded bolusesmales

   In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans: evidence for relative GHRH deficiency in aging

   The Journal of clinical endocrinology and metabolism·Oct 1, 1999

More on Growth hormone-releasing hormone

1. Pilocarpine increases growth hormone secretion in rats.

   “systemic administration of pilocarpine, an agonist of muscarinic receptors, potentiates the GH response to GHRH during the entire lifespan.”

   Reviewin male rats of various agesmales

   Aspects of the neuroendocrine control of growth hormone secretion in ageing mammals

   Journal of reproduction and fertility. Supplement·Jan 1, 1993

More on Pilocarpine

1. Age is associated with growth hormone secretion in humans (14% decline per decade).

   “GH secretion on the average declines by 14% with each decade in normal adults after 20 years of age.”

   Reviewnormal adultseach decade

   Growth hormone therapy in elderly people: an age-delaying drug?

   Fundamental & clinical pharmacology·Jan 1, 1996