Glyphosate

1. Glyphosate induces cellular senescence in cells.

   “prolonged exposure to occupationally relevant glyphosate concentrations increases susceptibility to oxidative stress, accelerating senescence in lung and dermal fibroblasts”

   Cellslung and dermal fibroblasts

   Antioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations

   Environmental toxicology and pharmacology·Jul 13, 2026

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1. Glyphosate has no effect on telomere length in cells.

   “Telomere length remained unchanged, though proliferative capacity was reduced in these cells.”

   CellsP10 fibroblasts

   Antioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations

   Environmental toxicology and pharmacology·Jul 13, 2026

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1. Glyphosate increases malondialdehyde in cells.

   “malondialdehyde, protein carbonyl, and 8-hydroxy-deoxyguanosine levels, p16, p21, p53, HO-1, NRF2, and NQO-1 genes were upregulated in P10 fibroblasts”

   CellsP10 fibroblasts

   Antioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations

   Environmental toxicology and pharmacology·Jul 13, 2026

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1. Glyphosate decreases cell viability in cells.

   “cell viability to H2O2 challenge was reduced in P1 and P10 fibroblasts”

   CellsP1 and P10 fibroblasts

   Antioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations

   Environmental toxicology and pharmacology·Jul 13, 2026

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1. Glyphosate decreases glutathione S-transferase in Cynopoecilus sp..

   “senile subjects were negatively impacted by the exposure to formulations containing glyphosate, and this was related to a loss of glutathione S-transferase activity.”

   Animalsin senile individuals exposed to Roundup Original

   Development stage-dependent oxidative stress responses to the exposure to roundup original© in a neotropical annual killifish

   Environmental toxicology and pharmacology·Sep 12, 2022

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1. Glyphosate increases lipid peroxidation in Cynopoecilus sp. (2-fold).

   “senile individuals presented 2-fold higher lipid peroxidation levels associated with the maintenance of superoxide dismutase and catalase activity levels even after exposure to the herbicide”

   Animalsin senile individuals exposed to Roundup Original

   Development stage-dependent oxidative stress responses to the exposure to roundup original© in a neotropical annual killifish

   Environmental toxicology and pharmacology·Sep 12, 2022

More on Lipid peroxidation