Glycodeoxycholic acid

Glycodeoxycholic acid has been studied in 2 papers since 2025: none in people yet, 2 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 31, 2026: “Blood bile acid patterns differed by sex and dementia status”.

Intervention

2 papers study it4 more mention it5 findingsUpdated

PubChemChEBI

1 new paper in 30 daysSee all 6 papers on glycodeoxycholic acid

At a glance

The findings reach mice, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.
  • 2 independent labs in 1 country
  • Funders: National Natural Science Foundation of China and 7 more
  • Animals2

What did studies of glycodeoxycholic acid find?

5

Studies of glycodeoxycholic acid measured 5 outcomes, among them GLP-1 secretion, brown adipose tissue thermogenesis and hepatic steatosis.

GLP-1 secretion

upin mice1

1 study
  1. Glycodeoxycholic acid increases GLP-1 secretion in mice (obese mice; through TGR5 signaling).

    “which enhanced brown adipose tissue (BAT) thermogenesis and stimulated ileal glucagon-like peptide-1 (GLP-1) secretion”

    Animalsobese mice; through TGR5 signalingileum

    Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion

    Acta pharmaceutica Sinica. B

More on GLP-1 secretion

Brown adipose tissue thermogenesis

upin mice1

1 study
  1. Glycodeoxycholic acid increases brown adipose tissue thermogenesis in mice (obese mice; through TGR5 signaling).

    “GDCA exerted anti-obesity effects by activating the TGR5 signaling, which enhanced brown adipose tissue (BAT) thermogenesis”

    Animalsobese mice; through TGR5 signalingbrown adipose tissue

    Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion

    Acta pharmaceutica Sinica. B

Hepatic steatosis

downin mice1

1 study
  1. Glycodeoxycholic acid decreases hepatic steatosis in mice (obese mice).

    “GDCA supplementation in obese mice markedly improved body weight, hepatic steatosis, and metabolic dysfunction.”

    Animalsobese miceliver

    Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion

    Acta pharmaceutica Sinica. B

More on Hepatic steatosis

Body weight

downin mice1

1 study
  1. Glycodeoxycholic acid decreases body weight in mice (obese mice).

    “GDCA supplementation in obese mice markedly improved body weight, hepatic steatosis, and metabolic dysfunction.”

    Animalsobese mice

    Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion

    Acta pharmaceutica Sinica. B

Physical function

downin mice1

1 study
  1. Glycodeoxycholic acid impairs physical function in mice.

    “GDCA also acutely reduces mobility.”

    Animalsacute-exposure

    Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain

    bioRxiv : the preprint server for biologyPreprint

Latest

Dec 2025: 1Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 03 papers in 12 months
Frontiers in Endocrinology

Blood bile acid patterns differed by sex and dementia status

Total blood bile acid levels were 2.2-fold those in controls among Austrian dementia patients; associations varied by age and sex.Total blood bile acid levels were 2.2-fold those in controls among Austrian dementia patients; associations varied by age and sex.

Accepted, not yet published: case-control studyMechanisms