GLP-1 secretion

1. Glycodeoxycholic acid increases GLP-1 secretion in mice (obese mice; through TGR5 signaling).

   “which enhanced brown adipose tissue (BAT) thermogenesis and stimulated ileal glucagon-like peptide-1 (GLP-1) secretion”

   Animalsobese mice; through TGR5 signalingileum

   Gut microbiota drives the metabolic dysregulation in obesity-prone individuals by impairing GDCA-mediated activation of brown adipose thermogenesis and ileal GLP-1 secretion

   Acta pharmaceutica Sinica. B·Dec 7, 2025

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1. Caloric restriction showed no clear effect on GLP-1 secretion in rats (p ≥ 0.25 basal; p ≥ 0.14 in response to macronutrients and bile acids).

   “Secretion of cholecystokinin, gastrin, glucose-dependent insulinotropic peptide, GLP-1, neurotensin, and somatostatin was not affected by WL during basal conditions (p ≥ 0.25)”

   Animalsbasal conditions and in response to macronutrients and bile acids, compared with diet-induced obese ratsn = 7

   Weight loss by calorie restriction does not alter appetite-regulating gut hormone responses from perfused rat small intestine

   Acta physiologica (Oxford, England)·Feb 10, 2023

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1. Olaparib increases GLP-1 secretion in human cells (glucose-stimulated secretion).

   “Olaparib significantly enhanced secretion of the incretin, GLP-1”

   Cellsglucose-stimulated secretionNCI-H716

   PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells

   Aging and disease·Feb 1, 2018

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