GLP-1 receptor agonists + healthy lifestyle

1. GLP-1 receptor agonists + healthy lifestyle lowers the risk of major adverse cardiovascular events in humans (HR 0.50, 95% CI 0.38-0.65).

   “combination of adherence to healthy lifestyle and use of GLP-1 RAs together was associated with a 50% reduction in MACE compared to veterans with a lower adherence to a healthy lifestyle and no GLP-1 RAs usage”

   Humansin US veterans with type 2 diabetes

   Combined associations of GLP-1 medications and healthy lifestyle with cardiovascular outcomes among individuals with diabetes: The Million Veteran Program

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Major adverse cardiovascular events