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Glial cell line-derived neurotrophic factor

Intervention

1 paper4 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 4 of 4 findings with company ties
  • Animals1

Outcomes

4

Choline acetyltransferase

upin rats1

1 study

  1. Glial cell line-derived neurotrophic factor increases choline acetyltransferase in rats.

    “glial cell line-derived neurotrophic factor and nerve growth factor increased choline acetyltransferase activity in the septum, hippocampus, striatum and cortex of aged rats”

    Animalschronic intraventricular infusionsstriatum10 mg/day14 daysmales

    Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

    Neuroscience1 Apr 1997

More on Choline acetyltransferase

Tyrosine hydroxylase

upin rats1

1 study

  1. Glial cell line-derived neurotrophic factor increases tyrosine hydroxylase in rats.

    “Glial cell line-derived neurotrophic factor significantly increased tyrosine hydroxylase activity in the substantia nigra and striatum of aged rats”

    Animalschronic intraventricular infusionssubstantia nigra10 mg/day14 daysmales

    Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

    Neuroscience1 Apr 1997

More on Tyrosine hydroxylase

Body weight

downin rats1−10% weight gain

1 study

  1. Glial cell line-derived neurotrophic factor decreases body weight in rats (-10% weight gain).

    “Both glial cell line-derived neurotrophic factor and nerve growth factor reduced weight gain by 10% in young and old F344 rats.”

    Animalschronic intraventricular infusions10 mg/day14 daysmales

    Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

    Neuroscience1 Apr 1997

Locomotor activity

upin rats1+242%

1 study

  1. Glial cell line-derived neurotrophic factor increases locomotor activity in rats (+242%).

    “In glial cell line-derived neurotrophic factor-treated aged and young rats there was significantly increased (242% and 149%, respectively) locomotor activity measured at seven days.”

    Animalschronic intraventricular infusions10 mg/day7 daysmales

    Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

    Neuroscience1 Apr 1997

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