Flortaucipir

7 papers1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans7

Associations

Universal tau PET scale

no changein humans1

1 study

Flortaucipir is associated with universal tau PET scale in humans (11.0 vs 11.0).
“The most liberal Uniτ threshold for T+ was 11.0 for both MK6240 and Flortaucipir, closely matching the 50% TVR+ probability threshold (11.1 for MK6240 and 11.7 for Flortaucipir).”
Humansacross aging and Alzheimer's disease spectrumbrainn = 485
Defining tau PET positivity grey zones for MK6240 and Flortaucipir quantification
AAIC 2025 abstract23 Dec 2025

Latest

60 in 12 months

Nature Communications4 Oct

Brain metabolism model predicts Alzheimer tau in humans

Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with 79% to 95%…Trained on 1,088 participants, the machine learning framework predicted flortaucipir-PET with R² values of 0.34 to 0.71 and classified tau stages with 79% to 95% accuracy.

Computational studyAlzheimer's disease

Paper

Neuropsychopharmacology23 Sep