Universal tau PET scale

1. Tau pathology visual read positivity is associated with universal tau PET scale in humans (11.0 to 24.6 Uniτ across 50% to 99% TVR+ probabilities).

   “Higher TVR+ probabilities corresponded to increased Uniτ values with MK6240 and Flortaucipir showing near‐identical values between the tracers”

   Humansin aging and AD spectrum individuals

   Defining tau PET positivity grey zones for MK6240 and Flortaucipir quantification

   AAIC 2025 abstract·8 Jan 2026

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1. Flortaucipir is associated with universal tau PET scale in humans (11.0 vs 11.0).

   “The most liberal Uniτ threshold for T+ was 11.0 for both MK6240 and Flortaucipir, closely matching the 50% TVR+ probability threshold (11.1 for MK6240 and 11.7 for Flortaucipir).”

   Humansacross aging and Alzheimer's disease spectrumbrainn = 485

   Defining tau PET positivity grey zones for MK6240 and Flortaucipir quantification

   AAIC 2025 abstract·23 Dec 2025

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