Evaluation discrepancy between [ ¹⁸ F]MK‐6240 and [ ¹⁸ F]AV‐1451 tau‐PET using tau‐PET overlap index

Abstract

Background: The overlap index (OI), previously introduced by Lee et al. (2022), has proven to be a reliable method for detecting tau accumulation via tau‐PET imaging with flortaucipir ([ ¹⁸ F]AV‐1451). This technique identifies voxel‐wise increases in standardized uptake value ratio (SUVr) across serial scans.