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Ferric citrate

Ferric citrate has been studied in 2 papers since 2023: 1 observational study in people, 1 in animals. The newest paper, Sep 7, 2023: “Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex-dependent manner”.

Intervention

2 papers study it4 more mention it4 findingsUpdated

PubChemMeSH

See all 6

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 3 independent labs in 3 countries
  • Funders: American Heart Association and 4 more
  • 1 of 4 findings with company ties
  • Humans1
  • Animals1

What did studies of Ferric citrate find?

4

Studies of Ferric citrate measured 4 outcomes; the most studied are cellular senescence (1 study), cognitive function (1) and TRIM63 (1).

Cellular senescence

upin mice1

1 study

  1. Ferric citrate induces cellular senescence in mice (chronically treated with ferric citrate).

    “their brains and the brain vasculature showed senescence-associated phenotype”

    Animalschronically treated with ferric citratebrainfemales

    Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex-dependent manner

    Aging cell

More on Cellular senescence

Cognitive function

downin mice1

1 study

  1. Ferric citrate impairs cognitive function in mice (chronically treated with ferric citrate).

    “aged female mice, but not males, showed cognitive deficits when chronically treated with ferric citrate (FC)”

    Animalschronically treated with ferric citratefemales

    Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex-dependent manner

    Aging cell

TRIM63

downin mouse cells1

1 study

  1. Ferric citrate decreases TRIM63 in C2C12 myocytes treated with deferoxamine (-31%, P = 0.04).

    “which was reversed by ferric citrate (-31%, P = 0.04 and -26%, P = 0.004, respectively).”

    Cellsin C2C12 myocytes treated with deferoxamine

    Iron deficiency is related to lower muscle mass in community-dwelling individuals and impairs myoblast proliferation

    Journal of cachexia, sarcopenia and muscle

More on TRIM63

Myoblast-to-myotube differentiation

downin mouse cells1

1 study

  1. Ferric citrate impairs myoblast-to-myotube differentiation in mouse cells.

    “ferric citrate induced ferroptosis in C2C12 cells, as well as impaired their differentiation”

    CellsC2C12 cells

    Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)

    International journal of biological sciences

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