Farnesyltransferase inhibitor
2 papers1 finding
- 1 lab in 1 country
- Funders: Maryland Stem Cell Research Fund and 6 more
- Animals1
- Cells1
Outcomes
1Osteogenesis
upin human cells1
1 study
Osteogenesis
upin human cells1
Farnesyltransferase inhibitor improves osteogenesis in human cells.
“Blocking farnesylation of progerin restores active β-catenin accumulation in the nucleus, increasing signaling, and ameliorates the defective osteogenesis.”
Cellsin HGPS patient-derived iPSCs
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Aug 2018
Latest
Journal of Bone and Mineral Research
Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria
Experiments in miceStem cell differentiation