Farnesyltransferase inhibitor

Intervention

2 papers1 finding

  • 1 lab in 1 country
  • Funders: Maryland Stem Cell Research Fund and 6 more
  • Animals1
  • Cells1

Outcomes

1

Osteogenesis

upin human cells1

1 study
  1. Farnesyltransferase inhibitor improves osteogenesis in human cells.

    “Blocking farnesylation of progerin restores active β-catenin accumulation in the nucleus, increasing signaling, and ameliorates the defective osteogenesis.”

    Cellsin HGPS patient-derived iPSCs

    Diminished Canonical β-Catenin Signaling During Osteoblast Differentiation Contributes to Osteopenia in Progeria

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Aug 2018

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