F1462

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 2 more
  • Cells1

Outcomes

2

Vascular wall thickening

downin mice1

1 study
  1. F1462 decreases vascular wall thickening in mice.

    Animalsin naturally aged mice

    Novel SIRT1 up-regulator F1462 attenuates endothelial cell senescence and vascular aging by promoting mitochondrial biogenesis via activating the SIRT1/PGC-1α/TFAM pathway

    European journal of pharmacology20 Aug 2026

Mitochondrial biogenesis (PGC-1α)

upin human cells1

1 study
  1. F1462 activates mitochondrial biogenesis (PGC-1α) in human cells.

    Cellsin a DOX-induced EC senescence model

    Novel SIRT1 up-regulator F1462 attenuates endothelial cell senescence and vascular aging by promoting mitochondrial biogenesis via activating the SIRT1/PGC-1α/TFAM pathway

    European journal of pharmacology20 Aug 2026

More on Mitochondrial biogenesis (PGC-1α)

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