AgingResearch.NewsJoin free

EUK-207

EUK-207 has been studied in 1 paper since 2019: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Jan 28, 2019: “ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation”.

Intervention

1 paper studies it4 findingsUpdated

PubChemMeSH

See all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Fondation de l'Avenir pour la Recherche Médicale Appliquée
  • 4 of 4 findings with company ties
  • Animals1

What did studies of EUK-207 find?

4

Studies of EUK-207 measured 4 outcomes; the most studied are hair cell degeneration (1 study), age-related hearing loss (1) and cellular senescence (1).

Hair cell degeneration

downin mice1

1 study

  1. EUK-207 decreases hair cell degeneration in mice.

    “systemic administration of EUK-207 reduced age-related loss of hearing and hair cell degeneration in senescence-accelerated mouse-prone 8 (SAMP8) mice.”

    Animalssenescence-accelerated mouse-prone 8 (SAMP8)sensory hair cell

    ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

    Molecular neurobiology

Age-related hearing loss

downin mice1

1 study

  1. EUK-207 decreases age-related hearing loss in mice.

    “systemic administration of EUK-207 reduced age-related loss of hearing and hair cell degeneration in senescence-accelerated mouse-prone 8 (SAMP8) mice.”

    Animalssenescence-accelerated mouse-prone 8 (SAMP8)

    ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

    Molecular neurobiology

More on Age-related hearing loss

Cellular senescence

downin mouse cells1

1 study

  1. EUK-207 decreases cellular senescence in mouse cells.

    “the synthetic superoxide dismutase/catalase mimetic EUK-207 attenuated H2O2-induced DNA damage and senescence phenotypes in cochlear cells in vitro.”

    Cellshydrogen peroxide exposurecochlear cell

    ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

    Molecular neurobiology

More on Cellular senescence

DNA damage

downin mouse cells1

1 study

  1. EUK-207 decreases DNA damage in mouse cells.

    “the synthetic superoxide dismutase/catalase mimetic EUK-207 attenuated H2O2-induced DNA damage and senescence phenotypes in cochlear cells in vitro.”

    Cellshydrogen peroxide exposurecochlear cell

    ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation

    Molecular neurobiology

Latest

Related